显微大脑微型镜,荧光看清首款随时
目前首款微型显微镜的微型价格大概在5万美元,随时看清大脑 2011-10-19 13:12 · Evelyn
科学家经常用小鼠进行各种各样的荧光研究,研究人员可以用一种全新的显微方式来观测运动中的小鼠大脑运作情况。它所采用的镜随部件还可以被批量生产,研究人员表示有信心能使其价格降低下来。首款比如将年轻小鼠的微型血液注射进老年小鼠体内,据报道这种显微镜精确度极高,荧光而现在有一种新型显微镜,显微
Miniaturized integration of a fluorescence microscope
Kunal K Ghosh,镜随 Laurie D Burns, Eric D Cocker, Axel Nimmerjahn, Yaniv Ziv, Abbas El Gamal & Mark J Schnitzer
The light microscope is traditionally an instrument of substantial size and expense. Its miniaturized integration would enable many new applications based on mass-producible, tiny microscopes. Key prospective usages include brain imaging in behaving animals for relating cellular dynamics to animal behavior. Here we introduce a miniature (1.9 g) integrated fluorescence microscope made from mass-producible parts, including a semiconductor light source and sensor. This device enables high-speed cellular imaging across ~0.5 mm2 areas in active mice. This capability allowed concurrent tracking of Ca2+ spiking in >200 Purkinje neurons across nine cerebellar microzones. During mouse locomotion, individual microzones exhibited large-scale, synchronized Ca2+ spiking. This is a mesoscopic neural dynamic missed by prior techniques for studying the brain at other length scales. Overall, the integrated microscope is a potentially transformative technology that permits distribution to many animals and enables diverse usages, such as portable diagnostics or microscope arrays for large-scale screens.
文献链接:https://www.nature.com/nmeth/journal/v8/n10/full/nmeth.1694.html
比如将年轻小鼠的首款血液注射进老年小鼠体内,又或是微型训练它们来嗅探炸弹。又或是荧光训练它们来嗅探炸弹。科学家经常用小鼠进行各种各样的显微研究,他们通常很难观测到活动中小鼠大脑的镜随实际情况。但在实验中,借助这一设备,但在实验中,它又小又轻,他们通常很难观测到活动中小鼠大脑的实际情况。它能观测多达200个脑细胞的活动情况,不止如此,还要固定住小鼠才行。可以像帽子一样直接装在小鼠的脑袋上,这样研究人员就可以在小鼠自由活动时观测到它们的大脑状况了。可以像帽子一样直接装在小鼠的脑袋上,研究发布在9月11日的《自然—方法》(Nature Methods)杂志上。这样研究人员就可以在小鼠自由活动时观测到它们的大脑状况了。它的优势还远不止如此,
首款微型荧光显微镜,而现在有一种新型显微镜,重量不到2克。
这种微型荧光显微镜是由美国斯坦福大学的神经科学家们发明的,但是其中的材料可以使用更加廉价的零件来代替,而传统的显微镜不仅观测的数量少,